LSI and Swiss researchers discover antibodies may trigger autoimmunity in severe COVID-19
COVID toes led an international group of researchers to identify a previously unknown role of Immunoglobulin A (IgA) in severe COVID-19. To date, over 50 million people have been affected by COVID-19 since the start of the pandemic. More than one million deaths have resulted from a range of virus-associated causes and complications, including acute […]
Acidity may play a role in esophageal cancer – and point the way to new treatment approaches
LSI and UBC Faculty of Medicine researchers have found that pH levels may play a key role in the metastasis of esophageal cancer as well as cellular changes that set the stage for its development. The findings, reported in a cover story appearing in Cellular and Molecular Gastroenterology and Hepatology by Postdoctoral Fellow Shane Duggan, […]
Circumventing selective permeability: small binding proteins hitch a ride into cell cytosol via salmonella’s sensory probe
LSI researchers have harnessed salmonella’s syringe-like system to inject specific proteins into the fluid that fills cells. More than a quarter of all human proteins are thought to bathe in this milieu, where they interact with one another as well as with proteins from every other cellular compartment. Yet until now, it’s been impossible to […]
In memory of Dr. Susanne Michelle Clee
Susanne Michelle Clee November 21, 1972 – July 17, 2020 Dr. Susanne Clee dedicated her life’s work to uncovering the physiological mechanisms by which genes influenced the risk of diabetes, obesity and cardiovascular disease. She was an extremely dedicated, rigorous and passionate scientist who made important discoveries throughout her still-blossoming academic career. Known by many […]
CIHR Project Grant Competition Spring 2019, Funded Projects
Congratulations to LSI PIs who were funded in the Spring 2019 Competition. Elucidating and disrupting the neural substrates of fear memory Principal Investigator: Mark S. Cembrowski Amount awarded: $963,900 Role of pyruvate dehydrogenase kinase 1 (PDK1) in triglyceride metabolism and heart health Principal Investigator: Susanne M. Clee Amount awarded: $807,076 Epigenetic regulation and function […]
CIHR Project Grant Competition Fall 2018, Funded Projects:
Congratulations to LSI PIs who were funded in the Fall 2018 Competition. Functional characterization of genomic DNA elements regulating epigenetic silencing Principal Investigator: Carolyn J. Brown Amount awarded: $971,550 Characterization of a novel cofactor for tissue factor (TF) that enhances its pro-thrombotic and pro-inflammatory activities Principal Investigator: Edward M. Conway Amount awarded: $826,200 Regulation of chromatin structure […]
Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel | Dr Filip van Petegem
A manuscript by Dr. Filip van Petegem’s LSI research team was recently published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS). You can find the full publication here: http://www.pnas.org/content/early/2018/10/18/1808733115. Excerpts below. Significance Calmodulin is a ubiquitous Ca2+-sensing protein that can bind to more than a 100 different targets. In […]
CIHR Project Grant Competition Funded Projects, Spring 2018
Congratulations to our LSI PIs who were funded in the Spring 2018 CIHR Project Grant Competition. The role of the palmitoylating enzyme, DHHC9, in the formation and function of neuronal connections Principal Investigator: Shernaz Bamji Amount awarded: $1,097,776 The how and and why of cholesterol catabolism in Mycobacterium tuberculosis Principal Investigator: Lindsay Eltis Amount awarded: $879,750 Regulation […]
The 14th D. Harold Copp Lecture: June 13th @ 4pm, LSC 2
Nahum Sonenberg, PhD Professor, FRS Gilman Cheney Chair in Biochemistry Goodman Cancer Research Center McGill University 2002 Robert L. Noble Prize 2005 Killam Prize 2008 Gairdner International Award 2014 Wolf Prize Translational control of cancer and brain Diseases via the mRNA cap-binding protein, eIF4E Dr. Sonenberg is the father of translational control that plays […]
How-To: Discover Genome BC Funding for Life Science Research and Commercialization
A joint how-to session with e@UBC As a recognized catalyst for government and industry, Genome BC invests in research, entrepreneurship and commercialization in life sciences to address challenges in key sectors such as health, forestry, fisheries and aquaculture, agrifood, energy, mining and environment. Join Genome BC’s Director of Industry Innovation, Pat Brady, as he describes […]