Jayachandran Kizhakkedathu

Professor

mail jay@pathology.ubc.ca

call 604-822-7085

location_on 4408

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Research Focus Teams

Blood, Rare Disease, COVID-19

Research Interests

Anticoagulation, Biodegradable Polymers, Blood Compatible Polymers, Polymer Chemistry and Therapeutics, Proteomics

Departments

Pathology & Laboratory Medicine, Centre for Blood Research, Chemistry

Bio

Dr. Kizhakkedathu's expertise combines advanced polymer chemistry with tailored biological analysis. His research career has been spent on matching the molecular level interactions of synthetic polymers with biological systems, to design novel biomaterials in a translational setting. Since joining the Department of Pathology and Laboratory Medicine, and the Centre for Blood Research (CBR) at the University of British Columbia, Dr. Kizhakkedathu has developed an interdisciplinary research program on the application of synthetic polymers. He take an integrative, interdisciplinary approach with an understanding of the pathophysiology of diseases in combination with well-designed biological assays and animal models towards the discovery of novel polymers as therapeutics. His research has been published in leading journals including Nature Biotechnology, Nature Materials, Science Translational Medicine, Nature Communications, Biomaterials and Journal of the American Chemical Society. Dr. Kizhakkedathu is an Associate Professor, Department of Pathology and Laboratory Medicine at the University of British Columbia. Dr. Kizhakkedathu is involved in the development of a scalable manufacturing process.

Education:

  • Ph.D. (Chemistry), Indian Institute of Chemical Technology, 2000
  • M.Sc. (Chemistry), Mahatma Gandhi University, India, 1994
  • B.Sc. (Chemistry), Mahatma Gandhi University, India, 1992

Awards:

  • UBC Award for Excellence in Basic Science Research, 2013
  • Career Investigator Award, Michael Smith Foundation for Health Research, July 2011 - June 2019
  • Excellence in Research and Discovery, UBC Department of Pathology, 2011
  • New Investigator Award in Transfusion Science, Canadian Institute of Health Research, March 2005 - February 2010

Recent Publications

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Anti-Inflammatory Effects of Polyglycerol Sulfates and Natural Polyanions in Type 2 Inflammation

Destabilization of PF4-antigenic complexes in heparin-induced thrombocytopenia

Interaction between the Polyelectrolytes Unfractionated Heparin and Universal Heparin Reversal Agents

Antithrombotic coating with sheltered positive charges prevents contact activation by controlling factor XII-biointerface binding

Long-Term Prevention of Biofilm Formation by Polycatechol-Based Supramolecular Assemblies with Low Molecular Weight Polymers on Surfaces

Identification of the proteolytic signature in CVB3-infected cells

Enzymatic conversion of human blood group A kidneys to universal blood group O

External Trigger Free Charge Switchable Cationic Ligands in the Design of Safe and Effective Universal Heparin Antidote

Inhibitors of Inorganic Polyphosphate and Nucleic Acids Attenuate in vitro Thrombin Generation in Plasma from Trauma Patients

Investigation on Adaptability and Applicability of Polymer-Mediated Cell Surface Engineering by Ligation with Transglutaminase

Development of an iron overload HepG2 cell model using ferrous ammonium citrate

Use of a recombinant deacetylase to convert A1 red blood cells to the acquired B phenotype for quality control purposes

Self-anticoagulant sponge for whole blood auto-transfusion and its mechanism of coagulation factor inactivation

The Microbiological Burden of Short-Term Catheter Reuse in Individuals with Spinal Cord Injury: A Prospective Study

Inhibitors of Polyphosphate and Neutrophil Extracellular Traps

Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design

Development of a High-Throughput Urosepsis Mouse Model

What's fishy about protamine? Clinical use, adverse reactions, and potential alternatives

Advances in Enhancing Hemocompatibility of Hemodialysis Hollow-Fiber Membranes

Sulfated Hyperbranched and Linear Polyglycerols Modulate HMGB1 and Morphological Plasticity in Neural Cells

Pharmacokinetics of small hyperbranched polyglycerols as an osmotic agent for peritoneal dialysis: Plasma exposure, organ distribution and excretion in rats

HyClear: A Novel Tissue Clearing Solution for One-Step Clearing of Microtissues

Robust Nanoparticle-Derived Lubricious Antibiofilm Coating for Difficult-to-Coat Medical Devices with Intricate Geometry

Active transport nanochelators for the reduction of liver iron burden in iron overload

Hydrophilic Polymer-Guided Polycatecholamine Assembly and Surface Deposition

DNAse Mediated Dissolution of Neutrophil Extracellular Traps (NETs) Accelerates in vitro Thrombin Generation Kinetics in Trauma Patients

Durable Surfaces from Film-Forming Silver Assemblies for Long-Term Zero Bacterial Adhesion without Toxicity

Influence of Steric Shield on Biocompatibility and Antithrombotic Activity of Dendritic Polyphosphate Inhibitor

Blood Compatibility of Hydrophilic Polyphosphoesters

Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs