Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

chevron_left
chevron_right

Direct Counting of mRNA Copies Inside Individual Lipid Nanoparticles Using In Situ Lysis and Labeling

Researcher: Cullis

Rapid adaptation accelerates competitive suppression in a parasite community

Researcher: King

Liposomal lipid nanoparticles containing dihydrosphingomyelin exhibit improved stability and extended hepatic and extrahepatic transfection

Researchers: Foster, Harder, Cullis

Advantages and limitations of in vitro models for atopic dermatitis: A consensus expert opinion

Researcher: Hedtrich

Distinct effects of disease-associated mutations in the proximal C-linker on negatively cooperative binding of cyclic nucleotides to the human HCN4 channel

Researchers: Van Petegem, Accili

Deletion of neurosecretory proteins GL and GM drives dual anti-obesity effects via appetite suppression and enhanced energy expenditure

Researcher: Penninger

European foulbrood disease and protein supplementation in honey bee (Apis mellifera L.) colonies pollinating highbush blueberries in British Columbia

Researcher: Foster

Diffusing caveolin-1 scaffolds regulate mechanosignalling

Researcher: Nabi

Formaldehyde metabolism in the biocatalytic upgrading of lignin

Researcher: Eltis

CLIC-dependent internalization of caveolin-1 to lysosomal vacuoles in response to osmotic regulation

Researcher: Nabi

Evolutionary refinement of the ZIKV 5' UTR dictates a trade-off between RNA stability and promoter accessibility

Researcher: Sagan

Tumor sialylation regulates G-CSF stability and promotes neutrophil-mediated immunosuppression in breast cancer

Researcher: Penninger

Bridging Simplicity and Depth in Single-Cell Proteomics: A Cost-Effective Workflow and an Expanded Framework for Data Evaluation

Researcher: Foster

Enzymatic cell-surface engineering with glycocalyx mimicking anti-oxidant and anti-inflammatory sulfated polymers for protection against inflammatory vascular injury

Researcher: Kizhakkedathu

Lipid@polymer hybrid nanoparticles for efficient siRNA transport across the lung barriers: Mechanistic insights into the role of Ionizable lipids

Researcher: Hedtrich