Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV

Researcher: Van Petegem

Gestational inhibition of CSF1R signaling using PLX5622 drives musculoskeletal changes in postnatal offspring

Researcher: Rosin

Urinary multi-omics reveal non-invasive diagnostic biomarkers in clear cell renal cell carcinoma

Researcher: Penninger

Single-Cell Proteomics Reveals Proteome Remodeling and Cellular Heterogeneity During NGF-Induced PC12 Neuronal Differentiation

Researcher: Foster

Subunits of adaptor protein complex-1 make distinct contributions to the virulence of Cryptococcus neoformans

Researcher: P Johnson

The AP-1 adaptor complex is required for cell surface modifications and the survival of Cryptococcus neoformans in phagocytic cells

Researcher: Tocheva

Transmission heterogeneity emerges from uncoupled parasite shedding and spreading

Researcher: King

Epstein-Barr virus and multiple sclerosis: Mechanisms, therapeutic implications, and emerging interventions

Researcher: Horwitz

AI proteomics: from protein identification to virtual cells

Researcher: Overall

A DLL1-culture system to propagate murine patrolling monocytes from bone marrow progenitors

Researcher: Harder

A Unified Developmental Timeline of Pigmented Ocular Tissues in the Mouse Eye

Researcher: van Raamsdonk

The GCP16-zDHHC9 S-acyltransferase complex: reciprocal effects on protein S-acylation and stability

Researcher: Bamji

Design and development of lipid nanoparticle formulations for brain gene therapy

Researcher: Cullis

A neurocutaneous NaV1.8 channelopathy underlies a genetic subtype of primary idiopathic hyperhidrosis

Researcher: van Petegem

Nutrient and non-nutrient regulators of insulin secretion

Researcher: J Johnson