Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV

Researcher: Van Petegem

A neurocutaneous NaV1.8 channelopathy underlies a genetic subtype of primary idiopathic hyperhidrosis

Researcher: van Petegem

Nutrient and non-nutrient regulators of insulin secretion

Researcher: J Johnson

Enhancing Healthy Longevity: A Scoping Review of Practices and Interventions

Researcher: Cheung

Roles of cGAS in pulmonary pathophysiology: a multifaceted regulator and an emerging therapeutic target

Researcher: Foster

Sex differences in the regulation and function of cellular immunity in Drosophila

Researchers: Rideout, Tanentzapf

Trust in government, public health authorities, health scientists and medical care providers and COVID-19 vaccines among Canadian adults

Researcher: Abraham

Context-dependent toxicity of human Tau isoforms in a Drosophila tauopathy model

Researcher: Allan

Transgene Sequence Codon Optimization and Composition Determines Replication Competence of Self-Amplifying RNA

Researchers: Jan, Sagan

Repairing Atp10D in C57Bl/6J mice restores protein expression but does not mitigate metabolic stress from high fat diet

Researcher: Molday

Engineering a Cytochrome P450 O-Demethylase for the Bioconversion of Hardwood Lignin

Researcher: Eltis

The abnormal C-terminus caused by DVL1 variants impacts Robinow syndrome phenotypes

Researcher: Richman

A reversible broad-spectrum antiviral targets the human V-ATPase VO domain

Researcher: Jean

Grey matter degeneration during multiple sclerosis is linked to activation of neuronal necroptosis by oxidized phosphatidylcholines

Researcher: Dong

The life history of recessive deleterious alleles as seen through the eyes of a honey bee (Apis mellifera)

Researcher: Foster