Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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Targeting Age-Associated Immune Senescence via Nanoparticle-Based Metabolic Reprogramming

Researcher: Cullis

From pancreas and islet resources to diabetes insights

Researcher: J Johnson

Membrane Proteome Remodeling in Female APP/PS1 Mice Following M1 Muscarinic Receptor Modulation Revealed by Peptidisc-Enabled DIA-MS

Researcher: Duong

Quality control of protein import into mammalian mitochondria

Researcher: Weidberg

The Structure-Activity Relationship and Anticoagulation Mechanism of Polyglycerol Sulfates of Different Architectures

Researcher: Kizhakkedathu

Drugging the intrinsically disordered transactivation domain of androgen receptor

Researcher: Strynadka

Clinical variability of ATP11C-related hemolytic anemia: expanding the phenotypic and diagnostic spectrum

Researcher: Molday

Data Science at the Interface of Air Pollution and Lung Health: Toward Precision Health

Researcher: Lim

Manipulation of Gene Expression in Mouse Pancreas via Intraductal Delivery of Adeno-Associated Viral Vectors

Researcher: J Johnson

Non-canonical proteolytic activation of RNase L by SARS-CoV-2 3CLpro offsets inactivation of OAS1 p46 antiviral signaling

Researcher: Overall

Glycemic control and blood product quality of Canadian blood donors with diabetes

Researchers: Devine, J Johnson

Broad-spectrum bactericidal synergy of silver-cannabichromene-cannabigerol triple combinations against healthcare-associated pathogens

Researcher: Thompson

Persistent organic pollutant concentrations in human pancreas correlate with markers of beta cell dysfunction

Researcher: J Johnson

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis

Researcher: Rideout

Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage in Drosophila females

Researcher: Rideout