Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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Modelling herpes simplex virus type 2 and Zika virus replication in mouse vaginal organoids and human vaginal spheroids

Researcher: Tokuyama

RYR1-related diseases patient-led international research workshop: Novel perspectives, treatments and interventions

Researcher: van Petegem

How lipid nanoparticles evolved from models of biological membranes to systems that enable RNA therapeutics

Researcher: Cullis

Organotypic vascularization improves maturation of human stem cell-derived islets and restores normoglycemia in diabetic mice

Researchers: J Johnson, Penninger

Checkpoint-Directed Glycoengineering Reprograms the Vascular Lumen for Siglec-Mediated Immune Regulation

Researcher: Kizhakkedathu

Zika virus produces two isoforms of the NS2A protein that play mutually exclusive roles in viral replication and virion assembly

Researcher: Sagan

CD248 expression in human adipose tissue is upregulated in obesity and following glucocorticoid exposure: a mediator of insulin resistance and adipose dysfunction?

Researcher: Conway

Within-host evolution and transmission of a human gut symbiont across ecological scales

Researcher: Tropini

Structural and kinetic mechanisms of state-dependent potassium channel inhibition

Researchers: Van Petegem, Fedida

Declining ribosome function limits oocyte longevity

Researcher: Greenblatt

LIN-44/Wnt controls developmental neurite pruning via UNC-43/CaMKII and PKC-2/PKC in Caenorhabditis elegans

Researcher: Mizumoto

Diminished sialoside binding in novel H5N1 influenza hemagglutinin variants identified in a human patient

Researcher: Tokuyama

Functional heterogeneity of arrhythmogenic KCNQ1 S1 mutants reveals dependence on the number of KCNE1 subunits in the IKs channel complex

Researcher: Fedida

Sex Differences Following Cardiac Arrest: A Conceptual Framework for Mechanisms and Translational Targets

Researcher: Cembrowski

The kinase homology and dimerization domains in retinal membrane guanylyl cyclase 1 form the binding interface for the calcium sensor GCAP1

Researchers: Van Petegem, Molday