Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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Structural and kinetic mechanisms of state-dependent potassium channel inhibition

Researchers: Van Petegem, Fedida

LIN-44/Wnt controls developmental neurite pruning via UNC-43/CaMKII and PKC-2/PKC in Caenorhabditis elegans

Researcher: Mizumoto

Diminished sialoside binding in novel H5N1 influenza hemagglutinin variants identified in a human patient

Researcher: Tokuyama

Functional heterogeneity of arrhythmogenic KCNQ1 S1 mutants reveals dependence on the number of KCNE1 subunits in the IKs channel complex

Researcher: Fedida

Sex Differences Following Cardiac Arrest: A Conceptual Framework for Mechanisms and Translational Targets

Researcher: Cembrowski

The kinase homology and dimerization domains in retinal membrane guanylyl cyclase 1 form the binding interface for the calcium sensor GCAP1

Researchers: Van Petegem, Molday

Degradomic and Transcriptomic Profiling Reveals Pleiotropic Roles of Extracellular Granzyme B in Scarring and Fibrosis

Researcher: Kizhakkedathu

The parental intestinal microbiome modulates systemic and local glucocorticoid levels in neonatal mice

Researcher: Harder

Genomic imprinting of the metabolic regulator gene Klf14 is regulated by a paternal sub-TAD anchored at Mest

Researcher: Lefebvre

Spatiotemporal development of sparse excitatory neuronal types within the deep mouse cortex

Researcher: Cembrowski

Single-cell-resolved genome atlas of prokaryoplankton inhabiting the ocean's interior

Researcher: Hallam

A Seven Amino Acid Long Region in the Cardiac Cav1.2, Encompassing Ser1487, Is Essential for Mice Embryonic Development and "Fight or Flight" Responses

Researcher: van Petegem

5-Carboxamide-Substituted Barbituric Acids: Promising Scaffolds for Drug Development against Mycobacterium tuberculosis

Researcher: Av-Gay

Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV

Researcher: Van Petegem

Generation of a human induced pluripotent stem cell panel from a family with a heterozygous RPS19 mutation including healthy wild-type, silent carrier and Diamond-Blackfan anemia individuals

Researcher: Penninger