Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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5-Carboxamide-Substituted Barbituric Acids: Promising Scaffolds for Drug Development against Mycobacterium tuberculosis

Researcher: Av-Gay

Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV

Researcher: Van Petegem

Generation of a human induced pluripotent stem cell panel from a family with a heterozygous RPS19 mutation including healthy wild-type, silent carrier and Diamond-Blackfan anemia individuals

Researcher: Penninger

Generation of high-quality reference control panels of human induced pluripotent stem cell clones from fibroblasts

Researcher: Penninger

Generation of high-quality reference control panels of human induced pluripotent stem cell clones from PBMCs

Researcher: Penninger

The comparative cell physiology of stem cell-derived and primary human β cells

Researcher: J Johnson

Methylome profiling of SetDB1-deficient ESCs reveals coordinated epigenetic cross-talk during pluripotency

Researcher: Lorincz

Metabolic engineering of Rhodococcus aromaticivorans RHA1 for muconic acid production from lignin

Researcher: Eltis

Epidermal growth factor receptor dysregulation and climate change: insights into pollution-promoted lung cancer

Researcher: Lim

Magneto-Mechanical Ball-Bearing Milling Induces Frequency-Dependent Structural Reorganization in Hybrid Multiphase Liposomes

Researcher: Cullis

Leishmania exosomal tRNA-derived small non-coding RNA fragments modulate host THP-1 derived macrophage proteins: A quantitative proteomic analysis

Researcher: Foster

Metagenome-assembled genomes for N2-fixing cyanobacterium Nostoc sp. TISTR 8405 and co-occurring microorganisms from a long-term laboratory culture

Researcher: Hallam

Osmotic conditions shape fitness gains and resistance mechanisms during E. coli and T4 phage co-evolution

Researcher: Tropini

Gestational inhibition of CSF1R signaling using PLX5622 drives musculoskeletal changes in postnatal offspring

Researcher: Rosin

Urinary multi-omics reveal non-invasive diagnostic biomarkers in clear cell renal cell carcinoma

Researcher: Penninger