Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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Discovery of functional factorless internal ribosome entry site-like structures through virome mining

Researcher: Jan

Investigation on the Influence of Protein Corona and Platelet Adhesion on Storage Bag Surface on the Platelet Storage Lesion

Researcher: Kizhakkedathu

Revealing function-altering MECP2 mutations in individuals with autism spectrum disorder using yeast and Drosophila

Researchers: Allan, Loewen

Consolidation of cell-ECM adhesion through direct talin-mediated actin linkage is essential for mouse embryonic morphogenesis

Researcher: Tanentzapf

Brownian dynamics simulation of the diffusion of rod-like nanoparticles in polymeric gels

Researcher: Hedtrich

Functional Analysis of Human EED Variants Using Drosophila

Researcher: Allan

Public Health Microbiome Curriculum: Looking Below the Tip of the Iceberg for Approaches to Population Health

Researcher: Tropini

Corrigendum to "Early-life gut inflammation drives sex-dependent shifts in the microbiome-endocrine-brain axis" [Brain Behav. Immun. 125 (2025) 117-139]

Researcher: Tropini

Neonatal Hippocampal Volume and Parent Structuring at 18 months in Relation to Cortisol Stress Regulation Across Early Childhood and Executive Functions at Age 4 Years in Children Born Very Preterm

Researcher: Weinberg

Laccase-catalyzed conversion of residual agricultural biomass to lignin-derived aromatic compounds

Researcher: Eltis

Autophagy-enhancing strategies to promote intestinal viral resistance and mucosal barrier function in SARS-CoV-2 infection

Researcher: Jean

Using the microbiota to study connectivity at human-animal interfaces

Researcher: King

No Evidence of Anti-Influenza Nucleoprotein Antibodies in Retail Milk from Across Canada (April-July 2024)

Researchers: Jean, Sagan

Widespread and cell-type-specific transcriptomic reorganization following mild traumatic brain injury

Researcher: Cembrowski

Functional and structural characterization of treatment-emergent nirmatrelvir resistance mutations at low frequencies in the mPro reveals a unique evolutionary route for SARS-CoV-2 to gain resistance

Researchers: Strynadka, Jean