Our research mission is to perform innovative, interdisciplinary science focused on discovering the fundamental biological mechanisms underlying health and disease and translating this knowledge into new therapies. As the largest institute of its kind in Canada, the LSI is positioned to take a lead in unraveling medicine’s greatest challenges and providing the data needed by the healthcare system through an evidence-based approach to achieve more precise management of health and treatment of disease.

Investigators at the LSI are initiating translational research projects that aim to change clinical practice, improve healthcare outcomes and potentially reduce healthcare costs by implementing an individualized approach to treatment. These projects are being developed in collaboration with the Personalized Medicine Initiative (PMI), industry, leading clinicians and the British Columbia healthcare system.

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Research in the LSI is focused on 9 disease or technology focused research groups. Members of these multi-disciplinary research groups conduct vibrant, biomedical-based research on diabetes, cardiovascular disease, immune responses, infectious disease, cancer biology, developmental disorders, bacterial regulation, neuroscience, structural biology, and molecular epigenetics. In addition to specific disease-oriented research, the LSI focuses on fundamental basic research in the biomedical sciences aimed at identifying, characterizing, and understanding the molecular mechanisms that govern gene expression, protein structure-function, environmental microbiology, and how key cellular and developmental processes go awry in human disease.

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