Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor

Researcher: Tropini

Lipid nanoparticle-based non-viral in situ gene editing of congenital ichthyosis-causing mutations in human skin models

Researcher: Hedtrich

Age-associated increases in PAI-1 silenced with siRNA-lipid nanoparticles reduces thrombosis and prolongs lifespan

Researcher: Cullis

Regularized Single-Cell Imaging Enables Generalizable AI Models for Stain-Free Cell Viability Screening

Researcher: Ma

Early-life microbiota skews long-term gene expression and chromatin states of bone marrow hematopoietic precursors

Researcher: Mohn

The role of Rho GTPases in facial morphogenesis

Researcher: Richman

Language model-guided anticipation and discovery of mammalian metabolites

Researcher: Foster

A Human-Based Skin-Lymphoreticular Model-on-Chip to Emulate Inflammatory Skin Conditions

Researcher: Hedtrich

The 2025 Report on the Human Proteome from the HUPO Human Proteome Project

Researcher: Overall

TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection

Researcher: Jean

Complete genome sequence of Escherichia coli EPI300

Researcher: Hallam

Generation of enzyme-converted type O whole blood from type A whole blood: A translational study using swine whole blood

Researcher: Kizhakkedathu

Identification of traumatic brain injury induced molecular signatures using spatial transcriptomics

Researcher: Cembrowski

Complete genome sequence of Caulobacter vibrioides CB2A JS4038

Researcher: Hallam

In mouse and in vitro models, bowel preparation promotes pathogen colonization, translocation, and exacerbation of inflammation

Researcher: Tropini