Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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Neonicotinoid-induced signature dysbiosis identified via metagenomic sequencing of the honey bee gut microbiome

Researcher: Foster

A direct role for a mitochondrial targeting sequence in signalling stress

Researchers: Weidberg, Wei, Yip

Lipid nanoparticle mediated base editing of the Q344X rhodopsin mutation associated with retinitis pigmentosa

Researchers: Cullis, Molday

Talin autoinhibition is required for normal hemostasis

Researchers: Tanentzapf, Kim

Trust Dynamics and Equity in Public Health in Canada: Protocol for a Mixed Methods Project in the Postpandemic Era

Researcher: Abraham

Predicting bacterial-mediated entomopathogenicity through comparative genomics and statistical modeling

Researcher: Haney

Comparative study of fetal facial shape between Japanese and North American populations using micro-CT

Researcher: Richman

Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets

Researcher: Van Petegem

Improved Immunohistochemistry of Mouse Eye Sections Using Davidson's Fixative and Melanin Bleaching

Researcher: Van Raamsdonk

Crystal structures of Ryanodine Receptor reveal dantrolene and azumolene interactions guiding inhibitor development

Researcher: Van Petegem

Cryo-EM analysis of the Staphylococcus aureus phenol-soluble modulin exporter PmtCD apo form in detergent micelles, nanodiscs and peptidiscs

Researcher: Strynadka

Membrane-mimetic thermal proteome profiling (MM-TPP) toward mapping membrane protein-ligand dynamic interactions

Researcher: Duong

The RANK/RANKL axis controls vascular dynamics in the bone marrow

Researcher: Penninger

Saskemycin, a potent and selective antimycobacterial agent targeting a unique site on the ribosome

Researcher: Av-Gay

Mating-induced patterns of spermathecal fluid protein expression in two eusocial insect species, Lasius niger and Apis mellifera

Researcher: Foster