Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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Talin autoinhibition is required for normal hemostasis

Researchers: Tanentzapf, Kim

Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets

Researcher: Van Petegem

Crystal structures of Ryanodine Receptor reveal dantrolene and azumolene interactions guiding inhibitor development

Researcher: Van Petegem

Cryo-EM analysis of the Staphylococcus aureus phenol-soluble modulin exporter PmtCD apo form in detergent micelles, nanodiscs and peptidiscs

Researcher: Strynadka

Membrane-mimetic thermal proteome profiling (MM-TPP) toward mapping membrane protein-ligand dynamic interactions

Researcher: Duong

The RANK/RANKL axis controls vascular dynamics in the bone marrow

Researcher: Penninger

Mating-induced patterns of spermathecal fluid protein expression in two eusocial insect species, Lasius niger and Apis mellifera

Researcher: Foster

"Just be honest with us": A qualitative analysis of Canadians' public trust during the COVID-19 pandemic

Researcher: Abraham

Azomycin produced by Pseudomonas has both phytotoxic and anti-oomycete activity

Researcher: Haney

nERdy: network analysis of endoplasmic reticulum dynamics

Researcher: Nabi

The tropomyosin 3.1/3.2 inhibitor ATM-3507 alters B-cell actin dynamics and impairs the growth and motility of diffuse large B-cell lymphoma cell lines

Researcher: Gold

Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA

Researcher: Yip

Finerenone prevents renal damage by enhancing SDF-1α/CXCR4-mediated stem cell mobilization in experimental type 1 diabetic nephropathy

Researcher: Overall

Impact of somatic XIST deletions on ongoing XIST expression and inactive X silencing and heterochromatin

Researcher: Brown

A bacterial exotoxin-triggered plant immune response restricts pathogen growth

Researcher: Haney