Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

chevron_left
chevron_right

Structural insights into insect-selective sodium channel toxins drive AI-enhanced biopesticide design

Researcher: Van Petegem

Microplastics and nanoplastics in the human gut: from signals to standards

Researcher: Tropini

Biological costs and benefits of selective breeding for disease resistance using marker-assisted or field-based selective breeding in honey bees (Apis mellifera)

Researcher: Foster

Integrating the Microbiome Into Infection Ecology and Evolution in Wild Animals

Researcher: King

Nasal budesonide mitigates air pollution effects in adults with allergic rhinitis: a randomized trial

Researcher: Lim

Shell-shocked: parasite-induced behaviour and development in an invasive dead-end snail host

Researcher: Foster

Divergent hippocampal output via covariant local and long-range neuronal structure

Researcher: Cembrowski

BamA self-insertion drives inner-to-outer membrane remodelling in diderm Firmicutes

Researcher: Tocheva

Microbial regulation of stress-associated signaling molecules and its role in health and disease

Researcher: Tropini

The most virulent parasite determines virulence in coinfection: a meta-analysis

Researcher: King

A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration

Researcher: Tanentzapf

An inter-subunit path is required for entropically-driven and negatively cooperative binding of cyclic nucleotides in the HCN2 channel

Researchers: Van Petegem, Accili

Polyglycerol-b-polyoxazoline: A next-generation biocompatible agent for diabetic wound treatment

Researcher: Hedtrich

The Drosophila wing is a high-throughput and versatile screening tool for Tau-mediated disease mechanisms and drug discovery

Researcher: Allan

A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor

Researcher: Tropini