Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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Talin autoinhibition is required for normal hemostasis

Researchers: Tanentzapf, Kim

A physiologically-relevant intermediate state structure of a voltage-gated potassium channel

Researchers: Van Petegem, Fedida

Enzyme-converted O kidneys allow ABO-incompatible transplantation without hyperacute rejection in a human decedent model

Researcher: Kizhakkedathu

Human assembloid of human blood vessel organoids with pancreatic islets improves insulin secretion over time ex vivo

Researcher: Penninger

Quantification and analysis of multiplexed fluorescence insitu hybridization data using open-source tools

Researcher: Cembrowski

EnGRAM: Engineering Open-Space Microfluidic Gradient Modulators

Researcher: Kaigala

Micro-scale control of oligodendrocyte morphology and myelination by the intellectual disability-linked protein acyltransferase ZDHHC9

Researcher: Bamji

Awareness, acceptance, and impact of undetectable equals untransmittable (U = U) among people living with HIV across Canada

Researcher: Murphy

Revisiting the evolution of the yeast Atg1 complex

Researcher: Yip

A-BioHPG: A Hydrophilic Biodegradable and Hemocompatible Hyperbranched/Dendritic Polyketal Polyglycerol with Tunable Degradation

Researcher: Kizhakkedathu

Framework for analyzing MAE-derived immunopeptidomes from cell lines with shared HLA haplotypes

Researcher: Foster

Integrative Omics and AI-Driven Systems Biology: Multilayer Networks Decoding Apis mellifera Health and Resilience

Researcher: Foster

Elucidation of a bacterial pathway for catabolism of the β-β-linked dilignol pinoresinol

Researcher: Eltis

Dehydration does not drive host behavioural manipulation by hairworms

Researcher: Foster

Cell type specific allometry controls sex-differences in Drosophila body size

Researcher: Kizhakkedathu