Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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Talin autoinhibition is required for normal hemostasis

Researchers: Tanentzapf, Kim

A Machine Learning Assisted Tool and Numerical Model for Analyzing Lipid Nanoparticles

Researcher: Cullis

Defining the Role of Integrins in Melanoblast Migration In Vivo

Researcher: Tanentzapf

GacA regulates symbiosis and mediates lifestyle transitions in Pseudomonas

Researcher: Haney

DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution

Researcher: Lim

From β soloist to endocrine symphony: Subtype-complete islets conduct glucose harmony

Researcher: Kieffer

Inside-out integrin activation is essential for early mammalian development

Researcher: Tanentzapf

Targeting DDX3X suppresses progression of KRAS-driven lung cancer by disrupting antioxidative homeostasis and inducing ferroptosis

Researcher: Penninger

A reliable micro-CT-based method reveals dynamic changes to alveolar bone and tooth root following ligature-induced periodontal injury in the mouse

Researcher: Graf

CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression

Researcher: Penninger

MilM from mildiomycin biosynthesis is an oxygen-, pyridoxal phosphate-dependent arginine hydroxylase

Researcher: Eltis

FERONIA Kinase Interacting Cell Wall Sensors LRX1/2 Regulate the Plant Rhizosphere Microbiome

Researcher: Haney

Investigation on Active and Rapid Hepatobiliary Excretion of Triantennary N-Acetyl Galactosamine Conjugated Polymeric Nanoparticles

Researcher: Kizhakkedathu

Multiparametric Characterization of Individual Suspended Nanoparticles Using Confocal Fluorescence and Interferometric Scattering Microscopy with Microfluidic Confinement

Researcher: Cullis

Reversing PAI-1 deficiency in blood using mRNA lipid nanoparticles

Researcher: Cullis