Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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A robust expression system reveals distinct gating mechanisms and calmodulin regulation of NaV1.9 channels

Researcher: Van Petegem

Anti-Inflammatory Effects of Polyglycerol Sulfates and Natural Polyanions in Type 2 Inflammation

Researchers: Hedtrich, Kizhakkedathu

Bat organoids reveal antiviral responses at epithelial surfaces

Researcher: Penninger

Altered activity within the social behavior neural network in adolescent rats following prenatal alcohol exposure and/or early-life adversity

Researcher: Weinberg

CSF-1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation

Researcher: Cembrowski

Generation of gastric proton pump atp4a knock-outs in Astyanax mexicanus. A fish model for insights into the mechanisms of acidification by oxynticopeptic cells

Researcher: Vogl

Leishmania regulates host YY1: Comparative proteomic analysis identifies infection modulated YY1 dependent proteins

Researcher: Foster

Metabolic mapping of the human solute carrier superfamily

Researcher: Penninger

Nicotinamide modulates gut microbial metabolic potential and accelerates recovery in mild-to-moderate COVID-19

Researcher: Penninger

Functional divergence of TBP homologs through distinct DNA-binding dynamics

Researcher: Teves

Characterization of a two-component kinase that initiates the bacterial catabolism of hydroxyphenylethanones

Researchers: Mohn, Eltis

Defining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an atypical mucinolytic protease, to penetrate mouse colonic mucus

Researcher: Foster

Functional imaging and connectome analyses reveal organizing principles of taste circuits in Drosophila

Researcher: Gordon

Liposomal lipid nanoparticles for extrahepatic delivery of mRNA

Researchers: Jan, Cullis

Dystroglycan mediates polarized deposition of Laminin and axon ensheathment by wrapping glia

Researcher: Auld