Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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MilM from mildiomycin biosynthesis is an oxygen-, pyridoxal phosphate-dependent arginine hydroxylase

Researcher: Eltis

FERONIA Kinase Interacting Cell Wall Sensors LRX1/2 Regulate the Plant Rhizosphere Microbiome

Researcher: Haney

Investigation on Active and Rapid Hepatobiliary Excretion of Triantennary N-Acetyl Galactosamine Conjugated Polymeric Nanoparticles

Researcher: Kizhakkedathu

Multiparametric Characterization of Individual Suspended Nanoparticles Using Confocal Fluorescence and Interferometric Scattering Microscopy with Microfluidic Confinement

Researcher: Cullis

Beyond genomics: a multiomics future for parasitology

Researcher: Foster

High-speed cell partitioning through reactive machine learning-guided inkjet printing

Researcher: Cheung

Antimicrobial peptide class that forms discrete β-barrel stable pores anchored by transmembrane helices

Researcher: Strynadka

Manufacturing stresses do not differentially impact red blood cells from donors with diabetes

Researchers: J Johnson, Devine

The Parkinson's drug benztropine possesses histamine receptor 1-dependent host-directed antimicrobial activity against Mycobacterium tuberculosis

Researcher: Av-Gay

Liposomal delivery of a disulfiram metabolite drives copper-mediated tumor immunity

Researcher: Cullis

Credible inferences in microbiome research: ensuring rigour, reproducibility and relevance in the era of AI

Researcher: Tropini

Unveiling tissue-specific transcriptional adaptations in iPSC-derived fibroblasts via co-culture systems

Researcher: Hedtrich

Graded activation of mutant K41C-KCNE1:KCNQ1 channel complexes by mefenamic acid

Researcher: Fedida

A Cross-Lagged Panel Analysis of Cortisol Levels and Internalizing Behaviors in Children Born Very Preterm Across Early Childhood: Associations Differ for Boys and Girls at Age 1.5 Years

Researcher: Weinberg

Predictive utility of placental hypothalamic-pituitary-adrenal axis biomarkers and infant neurodevelopment

Researcher: Weinberg