Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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Complete genome sequence of Escherichia coli EPI300

Researcher: Hallam

Generation of enzyme-converted type O whole blood from type A whole blood: A translational study using swine whole blood

Researcher: Kizhakkedathu

Identification of traumatic brain injury induced molecular signatures using spatial transcriptomics

Researcher: Cembrowski

Complete genome sequence of Caulobacter vibrioides CB2A JS4038

Researcher: Hallam

In mouse and in vitro models, bowel preparation promotes pathogen colonization, translocation, and exacerbation of inflammation

Researcher: Tropini

HIV-1 establishes immediate latency in T cells expressing the viral Nef protein

Researcher: Sadowski

The biosynthesis of N-acylated tryptazolone in Mycobacterium tuberculosis and related bacteria

Researcher: Eltis

Comparative Evaluation of Solid-Phase and Membrane Mimetic Strategies in Membrane Proteome Coverage and Disease-State Analysis

Researcher: Duong

Single-Particle Multiparametric Microscopy Reveals Structural, Size, and Payload Heterogeneity in mRNA-Loaded Lipid Nanoparticles

Researcher: Cullis

Evidence for Toxin-Encoding Coinfections Driving Intransitive Dynamics Between Allelopathic Phenotypes in Natural Yeast Populations

Researcher: King

Rethinking the Microenvironment's Role in Chemical-Induced Malignancy

Researcher: Lim

Neonicotinoid-induced signature dysbiosis identified via metagenomic sequencing of the honey bee gut microbiome

Researcher: Foster

A direct role for a mitochondrial targeting sequence in signalling stress

Researchers: Weidberg, Wei, Yip

Lipid nanoparticle mediated base editing of the Q344X rhodopsin mutation associated with retinitis pigmentosa

Researchers: Cullis, Molday

Electrophysiological Phenotyping of hiPSC-Derived Atrial Cardiomyocytes Using Automated Patch-Clamp: A Platform for Studying Atrial Inherited Arrhythmias

Researcher: Accili