Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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BamA self-insertion drives inner-to-outer membrane remodelling in diderm Firmicutes

Researcher: Tocheva

Microbial regulation of stress-associated signaling molecules and its role in health and disease

Researcher: Tropini

The most virulent parasite determines virulence in coinfection: a meta-analysis

Researcher: King

A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration

Researcher: Tanentzapf

An inter-subunit path is required for entropically-driven and negatively cooperative binding of cyclic nucleotides in the HCN2 channel

Researchers: Van Petegem, Accili

Polyglycerol-b-polyoxazoline: A next-generation biocompatible agent for diabetic wound treatment

Researcher: Hedtrich

The Drosophila wing is a high-throughput and versatile screening tool for Tau-mediated disease mechanisms and drug discovery

Researcher: Allan

A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor

Researcher: Tropini

Lipid nanoparticle-based non-viral in situ gene editing of congenital ichthyosis-causing mutations in human skin models

Researcher: Hedtrich

Age-associated increases in PAI-1 silenced with siRNA-lipid nanoparticles reduces thrombosis and prolongs lifespan

Researcher: Cullis

Regularized Single-Cell Imaging Enables Generalizable AI Models for Stain-Free Cell Viability Screening

Researcher: Ma

Early-life microbiota skews long-term gene expression and chromatin states of bone marrow hematopoietic precursors

Researcher: Mohn

The role of Rho GTPases in facial morphogenesis

Researcher: Richman

Language model-guided anticipation and discovery of mammalian metabolites

Researcher: Foster

A Human-Based Skin-Lymphoreticular Model-on-Chip to Emulate Inflammatory Skin Conditions

Researcher: Hedtrich