Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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Characterization of a two-component kinase that initiates the bacterial catabolism of hydroxyphenylethanones

Researchers: Mohn, Eltis

Defining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an atypical mucinolytic protease, to penetrate mouse colonic mucus

Researcher: Foster

Functional imaging and connectome analyses reveal organizing principles of taste circuits in Drosophila

Researcher: Gordon

Liposomal lipid nanoparticles for extrahepatic delivery of mRNA

Researchers: Jan, Cullis

Dystroglycan mediates polarized deposition of Laminin and axon ensheathment by wrapping glia

Researcher: Auld

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition

Researchers: Jan, J Johnson

A selfish supergene causes meiotic drive through both sexes in Drosophila

Researcher: Wei

MHC Diversity Across Time and Space

Researcher: King

Advances in Cell Replacement Therapies for Diabetes

Researcher: Kieffer

Within-host competition causes pathogen molecular evolution and perpetual microbiota dysbiosis

Researcher: King

Fate and state transitions during human blood vessel organoid development

Researcher: Penninger

Clinical translation of microbiome research

Researcher: Tropini

Escape from X-chromosome inactivation at KDM5C is driven by promoter-proximal DNA elements and enhanced by domain context

Researcher: Brown

Multimodal cell maps as a foundation for structural and functional genomics

Researcher: Foster

Western red cedar (Thuja plicata) beehives have no impact on honey bee (Apis mellifera) overwintering colony survival or detoxification enzyme expression

Researcher: Foster