Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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Talin autoinhibition is required for normal hemostasis

Researchers: Tanentzapf, Kim

Impact of somatic XIST deletions on ongoing XIST expression and inactive X silencing and heterochromatin

Researcher: Brown

A bacterial exotoxin-triggered plant immune response restricts pathogen growth

Researcher: Haney

Cadherin flow translates cortical chirality into left-right asymmetric cell division dynamics in Caenorhabditis elegans embryos

Researcher: Sugioka

Activity-targeted metaproteomics uncovers rare syntrophic bacteria central to anaerobic community metabolism

Researcher: Hallam

Corrigendum to "Resilience of the replacing dentition in adult reptiles" [Develop. Biol. 516 (2024) 71-81]

Researcher: Richman

Direct Therapeutic Modulation of RYR2 Activity by CMYA5

Researcher: Van Petegem

Elevated virus infection of honey bee queens reduces methyl oleate production and destabilizes colony-level social structure

Researcher: Foster

Vibration-Assisted Magnetic (VibroMag) Cell Separation for Robotic Liquid Handling Platforms

Researcher: Ma

Expanding the Reach of Membrane Protein-Ligand Interaction Studies Through the Integration of Mass Spectrometry and Membrane Mimetics

Researcher: Duong

Resonating with replicability: factors shaping assay yield and variability in microfluidics-integrated silicon photonic biosensors

Researcher: Cheung

Distinct Layer 6b transcriptomic subtypes parcellate the cortical mantle

Researcher: Cembrowski

Lipid-based nanoparticles external triggered release strategies in cancer nanomedicine

Researcher: Cullis

Phosphorylation of RYR1 at Ser2902 decreases Ca2+ leak in skeletal muscle and susceptibility to malignant hyperthermia and heat stroke

Researcher: Van Petegem

Glycosaminoglycans as Polyelectrolytes: Charge, Interactions, and Applications

Researcher: Kizhakkedathu