Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

chevron_left
chevron_right

Credible inferences in microbiome research: ensuring rigour, reproducibility and relevance in the era of AI

Researcher: Tropini

Unveiling tissue-specific transcriptional adaptations in iPSC-derived fibroblasts via co-culture systems

Researcher: Hedtrich

Graded activation of mutant K41C-KCNE1:KCNQ1 channel complexes by mefenamic acid

Researcher: Fedida

A Cross-Lagged Panel Analysis of Cortisol Levels and Internalizing Behaviors in Children Born Very Preterm Across Early Childhood: Associations Differ for Boys and Girls at Age 1.5 Years

Researcher: Weinberg

Predictive utility of placental hypothalamic-pituitary-adrenal axis biomarkers and infant neurodevelopment

Researcher: Weinberg

A proof-of-concept experimental-theoretical model to predict pesticide resistance evolution

Researcher: King

Eco-evolutionary robustness of wild bacterial communities to experimental perturbation

Researcher: King

Multilaboratory Untargeted Mass Spectrometry Metabolomics Collaboration to Identify Bottlenecks and Comprehensively Annotate A Single Dataset

Researcher: Foster

A hair-follicle reconstructed in vitro immunocompetent skin model for prediction of the sensitizing potential of chemicals

Researcher: Hedtrich

Lung tissue-optimized gene editing in human cystic fibrosis models following topical application of lipid nanoparticles

Researchers: Cullis, Hedtrich

High-throughput single cell motility analysis using nanowell-in-microwells

Researcher: Ma

Insulin/insulin-like growth factor signaling pathway promotes higher fat storage in Drosophila females

Researchers: Gordon, Rideout

Spatially Defined Post-manufacturing Loading of Nanoparticles into Hydrogel-Forming Microneedles

Researchers: Cullis, Hedtrich

Robinow syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease model

Researcher: Richman

Early innate immune response and evolution of a SARS-CoV-2 furin cleavage site inactive variant in bat cells

Researcher: Overall