The University of British Columbia
UBC - A Place of Mind
The University of British Columbia Vancouver campus
Life Sciences Institute
  • HOME
  • OUR SCIENCE
    • Home to 14 Canada Research Chairs
  • OUR IMPACT
  • COMMERCIALIZATION
    • Spinoffs and Technology
    • Industrial Collaboration
    • Resources for Entrepreneurs
  • SUPPORT THE LSI
  • Faculty & Staff
    • Principal Investigators
    • LSI Personnel
    • Career Opportunities
  • Students & Postdoctoral Fellows
    • Graduate Students & Postdoctoral Fellows
    • Undergraduate Opportunities
    • Graduate Student Association
    • Career Opportunities
  • News & Events
    • News
    • Events
  • Resources
    • Scientific Facilities & Core Services
    • Shared Equipment
    • LSC Safety & Operations
    • Sustainability
    • Omics & Phenotyping Portal
    • Room Booking
    • Wing Managers
    • Toolkit
    • Used Equipment
    • Grant Facilitation
    • Electronic Lab Notebooks
    • Space Policy
  • LSI Gallery
    • 2016-17 Exhibition
    • Submissions
  • Health, Safety & Wellbeing
    • COVID-19 Info
    • Mental Health Resources
    • Safety
  • REDI
    • Respect, Equity, Diversity, Inclusion
  • LOGIN

Steven Hallam

March 22, 2022

Research Interests

Microbial ecology, Biological Engineering, Bioinformatics, High-throughput Biology

Research Focus Teams

Ecosystem Health

Departments

Microbiology & Immunology

Contact

Email: shallam@mail.ubc.ca

Office Phone: 604–827–3420

Publications

Google Scholar

Lab Website

Hallam lab

  • Bio
  • Research Summary
  • Ongoing Projects
Bio
OpenClose

Steven Hallam is a University of California Santa Cruz and MIT trained molecular biologist, microbial ecologist, entrepreneur, and innovator. With over 20 years of experience in field and laboratory research and innovation at disciplinary interfaces, Hallam is an Associate Professor in the Department of Microbiology and Immunology at the University of British Columbia, Canada Research Chair in Environmental Genomics and Canadian Institute for Advanced Research Scholar in integrated microbial biodiversity, a program dedicated to studying the molecular, morphological and community complexity of the microbial world.

Following an undergraduate degree from Sarah Lawrence College concentrating on Biology and Religion, Steven spent several years working as an oncology research technician at the Montifiore Medical Center. He went on to receive a PhD from the University of California Santa Cruz where he conducted research on developmental regulation of neuronal asymmetry and synaptic remodeling. Motivated by this experience in network dynamics, Steven became a postdoctoral research fellow at the Monterey Bay Aquarium Research Institute and later, Massachusetts Institute of Technology, where he studied microbial ecology and environmental genomics.

Steven’s current academic research intersects microbial ecology, synthetic biology and bioinformatics with specific emphasis on the creation of functional screens and computational tools that reveal hidden metabolic powers of uncultivated microbial communities. His laboratory has developed MetaPathways, a modular annotation and analysis pipeline to predict metabolic interactions from environmental sequence information. Other research areas include the use of microfluidic digital chip technology for single-cell genome sequencing and biosensor development for environmental monitoring and enzyme discovery. He was recently elected a fellow in the American Association for the Advancement of Science for distinguished contributions to the fields of environmental genomics and microbial ecology.

Dr. Hallam has filed provisional patents applications on platform screening technology for biosensor development and biorefining process improvements through his faculty position with the University of British Columbia. He recently co-founded MetaMixis, a synthetic biology company that uses this screening technology to discover and evolve small molecules and industrial catalysts from uncultivated microbial communities inhabiting natural and engineered ecosystems.

Steven is an underwater enthusiast. A former NAUI SCUBA instructor and scientific diver he has had the opportunity to ride in deep-sea submersibles exploring slow spreading centers and interact with remotely operated vehicles probing hydrocarbon seeps on continental margins.

Research Summary
OpenClose

My lab investigates the ecological and biogeochemical roles of uncultivated microbial communities in natural and engineered ecosystems with a particular emphasis on defining metabolic interactions. We combine plurality and single-cell genome sequencing with functional screening and the development of computational tools to predict latent and expressed metabolic potential and recover genomic scaffolds with biotechnological applications. To permit improved metabolic pathway prediction from environmental sequence information we have developed MetaPathways, a modular annotation and analysis pipeline for pathway inference that uses the PathoLogic algorithm to map functional annotations onto the MetaCyc collection of reactions and pathways, and construct environmental Pathway/Genome Databases (ePGDBs) compatible with the editing and navigation features of Pathway Tools. We use MetaPathways to predict metabolic interactions between sequenced isolates or environmental clones that can be validated in co-culture experiments using traditional genetic and biochemical methods. Other project space includes the use of microfluidic digital chip technology for single-cell genome sequencing and the use of biosensors to detect small molecule production or substrate conversion by environmental clones in plate-based or cell-sorting screens.

Ongoing Projects
OpenClose

Visit the lab website for more detail: https://hallam.microbiology.ubc.ca/

Life Sciences Institute
Vancouver Campus
2350 Health Sciences Mall
Vancouver, BC Canada V6T 1Z3
Tel 604 827 3977
Fax 604 827 3922
Website www.lsi.ubc.ca
Email lsi.reception@ubc.ca
Find us on
    
Back to top
The University of British Columbia
  • Emergency Procedures |
  • Terms of Use |
  • Copyright |
  • Accessibility