Research Interests
Developmental Biology, Developmental epigenetics, Epigenetic silencing, Epigenetics, Imprinting
Research Focus Teams
Fertility, Rare Diseases, Cancer
Departments
Contact
Email: louisl@mail.ubc.ca
Office Phone: phone: 604–822–5310
Publications
Lab Website
Associate Professor, Medical Genetics, UBC (2011-present)
Assistant Professor, Medical Genetics, UBC (2003-2011)
Canada Research Chair in Genomic Imprinting (2003-2013)
Research Scholar, Michael Smith Foundation for Health Research (2003-2008)
Postdoctoral Fellow, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto (Dr. Andras Nagy) (1998-2003)
Postdoctoral Fellow, Wellcome/CRC (now Gurdon) Institute, Cambridge, UK (Prof. Azim Surani) (1994-1998)
PhD, Biochemistry & Molecular Biology, University of British Columbia (Prof. Michael Smith) (1987-1994)
BSc, Biochimie, Université Laval, Québec (1984-1987)
Therian mammals contain some strange genes which are only expressed from the maternally or only the paternally inherited chromosome. These are called imprinted genes. In humans, abnormal expression of imprinted genes is associated with a number of rare syndromes. We still know very little about imprinted genes, why they are imprinted and what their functions are in mammalian biology. Work in my laboratory at UBC uses the mouse as a model organism to study the function and mechanism of genomic imprinting during mammalian development.
Visit https://meg.lsi.ubc.ca/current-membership/dr-louis-lefebvre/l3-projects/ for more information