Natalie Strynadka

Distinguished Professor

mail natalie.strynadka@ubc.ca

call 604-822-0789

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Research Focus Teams

COVID-19, Tuberculosis, Antimicrobial Resistance

Research Interests

Antibiotic resistance, Antibiotics, Cell surface receptors, Membrane proteins, Microorganisms, Protein structure and function

Departments

Biochemistry & Molecular Biology, Centre for Blood Research

Bio

Dr. Strynadka received her B.Sc (Hons. Biochemistry) and PhD (Biochemistry) degrees at the University of Alberta where she studied macromolecular x-ray crystallography within the MRC group in Protein Structure and Function. She initiated her independent laboratory in 1997 and is currently Professor of Biochemistry and Molecular Biology at the University of British Columbia. Her group uses multi-disciplinary structural biology tools to study membrane protein assemblies involved in bacterial viability and pathogenicity, including those involved in cell wall biogenesis and membrane transport. The goal of her research is to use this atomic information to guide design of novel antibiotics and vaccines to treat bacterial infections. Dr. Strynadka's research program has been recognized internationally and she currently holds several awards including HHMI Senior International Scholar, Canada Research Chair Tier 1 in Antibiotic Discovery and Fellow of the Royal Societies of Canada and London.

  • Ph.D. University of Alberta, 1990
  • B.Sc. University of Alberta, 1984

Recent Publications

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Functional and structural characterization of treatment-emergent nirmatrelvir resistance mutations at low frequencies in the mPro reveals a unique evolutionary route for SARS-CoV-2 to gain resistance

Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH

Structure-Function Relationship of the β-Hairpin of Thermus thermophilus HB27 Laccase

Characterization of novel small molecule inhibitors of estrogen receptor-activation function 2 (ER-AF2)

Cryo-EM characterization of the anydromuropeptide permease AmpG central to bacterial fitness and β-lactam antibiotic resistance

An alternative broad-specificity pathway for glycan breakdown in bacteria

Kinetic comparison of all eleven viral polyprotein cleavage site processing events by SARS-CoV-2 Main Protease using a linked protein FRET platform

Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1

Cryo-EM analysis of S. aureus TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance

Structural Insights into Type III Secretion Systems of the Bacterial Flagellum and Injectisome

A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants

Identification of an optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2

Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria

Vinyl Halide-Modified Unsaturated Cyclitols are Mechanism-Based Glycosidase Inhibitors

Large-Scale Virtual Screening for the Discovery of SARS-CoV-2 Papain-like Protease (PLpro) Non-covalent Inhibitors

An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity

Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus

X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation

The Impact of Second Coordination Sphere Methionine-Aromatic Interactions in Copper Proteins

The hinge region of the Israeli acute paralysis virus internal ribosome entry site directs ribosomal positioning, translational activity and virus infection

Automated discovery of noncovalent inhibitors of SARS-CoV-2 main protease by consensus Deep Docking of 40 billion small molecules