Leonard Foster

Professor; Director, Life Sciences Institute

mail foster@msl.ubc.ca

call 604-822-8311

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Research Focus Teams

COVID-19, Cancer, Rare Disease, Cardiovascular, Diabetes, Tuberculosis

Research Interests

Infectious diseases, Proteomics

Departments

Biochemistry & Molecular Biology

Bio

Dr. Leonard Foster is Professor and Head of the Department of Biochemistry and Molecular Biology at the University of British Columbia (UBC). Dr. Foster grew up in northern BC and earned his B.Sc at SFU in 1996. He moved to Toronto to complete a doctoral degree in the cell biology and biochemistry of insulin's effects on adipocytes. From there he went to the University of Southern Denmark to study mass spectrometry and proteomics with Matthias Mann. In 2005 he took up his current position at UBC. Dr. Foster's group at UBC develops and applies quantitative proteomic methods to study host-pathogen interactions in a variety of systems.

Recent Publications

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Leishmania regulates host YY1: Comparative proteomic analysis identifies infection modulated YY1 dependent proteins

Defining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an atypical mucinolytic protease, to penetrate mouse colonic mucus

Optimizing imputation strategies for mass spectrometry-based proteomics considering intensity and missing value rates

Western red cedar (Thuja plicata) beehives have no impact on honey bee (Apis mellifera) overwintering colony survival or detoxification enzyme expression

Multimodal cell maps as a foundation for structural and functional genomics

Honey bee egg composition changes seasonally and after acute maternal virus infection

Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes

Protein bL38 facilitates incorporation of uL6 during assembly of the 50S subunit in Flavobacterium johnsoniae

Factors affecting heat resilience of drone honey bees (Apis mellifera) and their sperm

Role of the sarcin-ricin loop of 23S rRNA in biogenesis of the 50S ribosomal subunit

Preclinical assessment of splicing modulation therapy for ABCA4 variant c.768G>T in Stargardt disease

Regional patterns and climatic predictors of viruses in honey bee (Apis mellifera) colonies over time

Transfection Potency of Lipid Nanoparticles Containing mRNA Depends on Relative Loading Levels

Bile acid-induced metabolic changes in the colon promote Enterobacteriaceae expansion and associate with dysbiosis in Crohn's disease

Immunoproteomic discovery of Mycobacterium bovis antigens, including the surface lipoprotein Mpt83 as a T cell antigen useful for vaccine development.

Identifying and modeling the impact of neonicotinoid exposure on honey bee colony profit

Genetic engineering of megakaryocytes from blood progenitor cells using mRNA lipid nanoparticles.

HumanIslets.com: Improving accessibility, integration, and usability of human research islet data.

Differences in honeybee queen pheromones revealed by LC-MS/MS: Reassessing the honest signal hypothesis

Phosphate availability conditions caspofungin tolerance, capsule attachment and titan cell formation in Cryptococcus neoformans.

Beta-hydroxybutyrate promotes basal insulin secretion while decreasing glucagon secretion in mouse and human islets

Glutathione-mediated redox regulation in Cryptococcus neoformans impacts virulence

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease

What proteomics has taught us about honey bee (Apis mellifera) health and disease

Higher prevalence of sacbrood virus in Apis mellifera (Hymenoptera: Apidae) colonies after pollinating highbush blueberries

Development of automated proteomic workflows utilizing silicon-based coupling agents

Sex-Based Mechanisms of Cardiac Development and Function: Applications for Induced-Pluripotent Stem Cell Derived-Cardiomyocytes

Characterization of Argonaute-containing protein complexes in Leishmania-infected human macrophages

Pivotal functions and impact of long con-coding RNAs on cellular processes and genome integrity

Honey bee stressor networks are complex and dependent on crop and region

Mechanisms of pathogen and pesticide resistance in honey bees

Global interactome mapping reveals pro-tumorigenic interactions of NF-κB in breast cancer

Oral infectivity through carnivorism in murine model of Trypanosoma cruzi infection

Investigating trade-offs between ovary activation and immune protein expression in bumble bee (Bombus impatiens) workers and queens

A murine model of maternal micronutrient deficiencies and gut inflammatory host-microbe interactions in the offspring

Metagenomic analysis of the honey bee queen microbiome reveals low bacterial diversity and Caudoviricetes phages

Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry

Deep Learning-Enabled MS/MS Spectrum Prediction Facilitates Automated Identification Of Novel Psychoactive Substances

Leishmania infection upregulates and engages host macrophage Argonaute 1, and system-wide proteomics reveals Argonaute 1-dependent host response

Identification of Emerging Novel Psychoactive Substances by Retrospective Analysis of Population-Scale Mass Spectrometry Data Sets

British Columbia beekeeping revenues and costs: survey data and profit modeling

Indirect exposure to insect growth disruptors affects honey bee (Apis mellifera) reproductive behaviors and ovarian protein expression

Recent advances in targeting the "undruggable" proteins: from drug discovery to clinical trials

Cleavage of 14-3-3ε by the enteroviral 3C protease dampens RIG-I-mediated antiviral signaling

Truncated TDP-43 proteoforms diagnostic of frontotemporal dementia with TDP-43 pathology

Small-molecule dual inhibitors targeting heat shock protein 90 for cancer targeted therapy

Discovering Protein-Protein Interactions using Co-Fractionation-Mass Spectrometry with Label-Free Quantitation

Targeting bromodomain-containing proteins: research advances of drug discovery

Integration of data-independent acquisition (DIA) with co-fractionation mass spectrometry (CF-MS) to enhance interactome mapping capabilities

Breaking spore dormancy in budding yeast transforms the cytoplasm and the solubility of the proteome

The Effects of Helicobacter pylori-Derived Outer Membrane Vesicles on Hepatic Stellate Cell Activation and Liver Fibrosis In Vitro

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy

CRISPR-induced DNA reorganization for multiplexed nucleic acid detection

Ribosomes lacking bS21 gain function to regulate protein synthesis in Flavobacterium johnsoniae

Synaptic activity-dependent changes in the hippocampal palmitoylome

Fertility costs of cryptic viral infections in a model social insect

Impact of Azo Dyes and Ibuprofen on the Proteome of Serratia nematodiphila sp

The adult mouse proteome

Development of a Method Combining Peptidiscs and Proteomics to Identify, Stabilize, and Purify a Detergent-Sensitive Membrane Protein Assembly

Review of the Real and Sometimes Hidden Costs in Proteomics Experimental Workflows

Where protein structure and cell diversity meet

Thermal Proteome Profiling Reveals the O-GlcNAc-Dependent Meltome

Drone honey bees are disproportionately sensitive to abiotic stressors despite expressing high levels of stress response proteins

Proteomic Profiles of Staphylococcus aureus Strains Associated with Subclinical Bovine Mastitis

Phenomic analysis of the honey bee pathogen-web and its dynamics on colony productivity, health and social immunity behaviors

Proteomic analysis of metabolic pathways supports chloroplast-mitochondria cross-talk in a Cu-limited diatom

Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications