Filip van Petegem

Professor

mail filip.vanpetegem@ubc.ca

call 604-827-4267

location_on 2356

open_in_new Lab Website

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Research Focus Teams

Autism, Rare Diseases, Cardiovascular

Research Interests

Cardiovascular, Ion channel regulation, Membrane proteins, Protein structure and function

Departments

Biochemistry & Molecular Biology

Bio

Filip Van Petegem obtained his PhD in Biochemistry at Ghent University (Belgium) in 2002, where he was trained as an X-ray crystallographer. He then moved to UCSF for postdoctoral studies, investigating the structure and function of voltage-gated calcium channels. In 2007, he joined the Dept. of Biochemistry and Molecular Biology at UBC, where he was promoted to Full Professor in 2017. His lab uses electrophysiology and structural biology methods to study ion channels.

Recent Publications

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A robust expression system reveals distinct gating mechanisms and calmodulin regulation of NaV1.9 channels

Crystallographic, kinetic, and calorimetric investigation of PKA interactions with L-type calcium channels and Rad GTPase

Beyond NT-proBNP: Circulating Protein Biomarkers for Atrial Fibrillation in Heart Failure and Cardiomyopathy

Elemental mapping in single-particle reconstructions by reconstructed electron energy-loss analysis

Cryo-EM structures of ryanodine receptors and diamide insecticides reveal the mechanisms of selectivity and resistance

PirA- or PirB-binding nanobodies can protect whiteleg shrimp from the acute hepatopancreatic necrosis disease toxin

ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents

Cryo-EM investigation of ryanodine receptor type 3

Propofol binds and inhibits skeletal muscle ryanodine receptor 1.

Individuals and Families Affected by RYR1-Related Diseases - The Patient/Caregiver Perspective.

Structural and Functional Characterization of the Nucleotide-binding Domains of ABCA4 and their Role in Stargardt Disease.

The molecular basis of cereal mixed-linkage β-glucan utilization by the human gut bacterium Segatella copri.

Research Note: Clostridium perfringens NetB and CnaA neutralizing nanobodies in feed reduce the incidence of poultry necrotic enteritis

RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET

Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation

Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives

RNA Polymerase II transcription independent of TBP

RYR-1-Related Diseases International Research Workshop: From Mechanisms to Treatments Pittsburgh, PA, U.S.A., 21-22 July 2022

Structural and functional conservation of the activating Ca2+ binding site in inositol 1,4.5-trisphosphate and ryanodine receptors

Gap junctions mediate discrete regulatory steps during fly spermatogenesis

The effect of Mg2+ on Ca2+ binding to cardiac troponin C in hypertrophic cardiomyopathy associated TNNC1 variants

It takes two to tango: Rycals and ATP snuggle up to bind ryanodine receptors

Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277

Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy

Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations

Altered cyclic nucleotide-binding and pore opening in a diseased human HCN4 channel

Using hiPSC-CMs to Examine Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia