Research Focus Teams

COVID-19, Diabetes

Research Interests

Cancer, Cellular stress, Diabetes, Gene Regulation and Expression, mRNA, Translation

Departments

Biochemistry & Molecular Biology

Bio

  • BSc, Queen's University, 1994
  • PhD, Northwestern University, 1999
  • Postdoctoral Fellow, Stanford University, 1999-2005
  • Killam Award for Excellence in Mentoring in the mid-career category, 2017

Recent Publications

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Discovery of functional factorless internal ribosome entry site-like structures through virome mining

Liposomal lipid nanoparticles for extrahepatic delivery of mRNA

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition

Protein is expressed in all major organs after intravenous infusion of mRNA-lipid nanoparticles in swine.

Identification of the proteolytic signature in CVB3-infected cells

Factor-Dependent Internal Ribosome Entry Site and -1 Programmed Frameshifting Signal in the Bemisia-Associated Dicistrovirus 2

Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin

Cleavage of 14-3-3ε by the enteroviral 3C protease dampens RIG-I-mediated antiviral signaling

The structure and mechanism of action of a distinct class of dicistrovirus intergenic region IRESs

Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency

Targeting Nup358/RanBP2 by a viral protein disrupts stress granule formation