Dieter Brömme

Professor

mail dbromme@dentistry.ubc.ca

call 604-822-1787

location_on 4558

open_in_new Lab Website

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Research Focus Teams

TBD

Research Interests

Arthritis/Osteo-Arthritis, Auto-Immune Diseases, Bone Tissue, Proteases, Protein structure and function

Departments

Biochemistry & Molecular Biology, Oral Biological & Medical Sciences

Bio

Dr. Dieter Brömme is a nationally and internationally recognized biochemist whose main research has been on cysteine proteases, protease inhibitors and the role of cathepsins in human diseases. He is a Canada Research Chair in Proteases and Disease. His research aims to better understand how proteases work, where and when they are produced in the body, how they destroy tissues and how they can be stopped from doing this. His particular interest is focused on a group of proteases called cathepsins, which play a critical role in musculoskeletal, respiratory and cardiovascular diseases.

Many proteases are considered as potential drug targets for a large variety of diseases. By improving the knowledge of how proteases work and finding novel drugs inhibiting proteases, Dr. Brömme's research could lead to new treatments for degenerative and inflammatory disorders.

Recent Publications

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Salvia miltiorrhiza in osteoporosis: a review of its phytochemistry, traditional clinical uses and preclinical studies (2014-2024)

Immune regulatory and anti-resorptive activities of risedronate and zoledronate bisphosphonates in vivo and in vitro: The basis for their clinical usage in osteoporosis and Paget's disease.

Real-time analysis of osteoclast resorption and fusion dynamics in response to bone resorption inhibitors

Extracellular Matrix Remodeling in Atopic Dermatitis Harnesses the Onset of an Asthmatic Phenotype and Is a Potential Contributor to the Atopic March

Lycopene Improves Bone Quality and Regulates AGE/RAGE/NF-кB Signaling Pathway in High-Fat Diet-Induced Obese Mice