Research Interests
Anticoagulation, Biodegradable Polymers, Blood Compatible Polymers, Polymer Chemistry and Therapeutics, Proteomics
Research Focus Teams
Blood, Rare Disease, COVID-19
Departments
Pathology & Laboratory Medicine, Centre for Blood Research, Chemistry
Contact
Email: jay@pathology.ubc.ca
Office Phone: phone: 604–822–7085
Publications
Lab Website
Dr. Kizhakkedathu’s expertise combines advanced polymer chemistry with tailored biological analysis. His research career has been spent on matching the molecular level interactions of synthetic polymers with biological systems, to design novel biomaterials in a translational setting. Since joining the Department of Pathology and Laboratory Medicine, and the Centre for Blood Research (CBR) at the University of British Columbia, Dr. Kizhakkedathu has developed an interdisciplinary research program on the application of synthetic polymers. He take an integrative, interdisciplinary approach with an understanding of the pathophysiology of diseases in combination with well-designed biological assays and animal models towards the discovery of novel polymers as therapeutics. His research has been published in leading journals including Nature Biotechnology, Nature Materials, Science Translational Medicine, Nature Communications, Biomaterials and Journal of the American Chemical Society. Dr. Kizhakkedathu is an Associate Professor, Department of Pathology and Laboratory Medicine at the University of British Columbia. Dr. Kizhakkedathu is involved in the development of a scalable manufacturing process.
Ph.D. (Chemistry), Indian Institute of Chemical Technology, 2000
M.Sc. (Chemistry), Mahatma Gandhi University, India, 1994
B.Sc. (Chemistry), Mahatma Gandhi University, India, 1992
UBC Award for Excellence in Basic Science Research, 2013
Career Investigator Award, Michael Smith Foundation for Health Research, July 2011 – June 2019
Excellence in Research and Discovery, UBC Department of Pathology, 2011
New Investigator Award in Transfusion Science, Canadian Institute of Health Research, March 2005 – February 2010
Our research program at the Centre for Blood Research, University of British Columbia is based on tailoring the molecular level interactions of synthetic polymers with biological systems to design novel biomaterials in a translational setting. We take an integrative, interdisciplinary approach with an understanding of the pathophysiology of diseases and advanced polymer synthesis in combination with well-designed biological assays and animal models towards the discovery of novel polymers as therapeutics, and technologies for biomedical and clinical use. Primarily my lab engages in four independent, yet closely related research themes:
Macromolecular Therapeutics
Cell-Surface Engineering
Proteomic Reagents
Blood-Compatible Surfaces and Devices
Major research projects include:
- The development of synthetic polymers as bioactive pharmaceuticals for unmet clinical needs in iron chelation therapy and anticoagulation therapy
- The development of novel methods for the prevention of immunological rejection of donor cells, tissues/organs
- Polymer based proteomic reagents for the analysis of blood proteome, iv) the development of biocompatible and antimicrobial coatings for biomedical devices and implants.