Clinical Associate Professor
Adjunct Scientist, R&D Canadian Blood Services
President & CTO, LightIntegra Technology Inc.

Research Interests
Research Summary

Development and evaluation of new methods of detection for platelet function in the context of transfusion medicine or clinical pathology of bleeding disorders; Dynamic light scattering and its application in platelet quality control, microparticle and bacterial detection, characterization of formulations for liposomal drug delivery and protein biochemistry; Determination of platelet serotonin, specifically in genetic disorders and the effect of selective serotonin reuptake inhibitor (SSRI) antidepressants; Application of biophysical techniques for analysis and understanding of platelet quality and platelet-related diseases.

The main focus of research in Dr. Maurer’s laboratory is the use of light scattering, in particular dynamic light scattering, to determine the shape of platelets, the number of microparticles and the response to temperature change as an indicator of platelet quality. The technology has been implemented in a method and device called the ThromboLUX, which is intended for pre-transfusion platelet quality testing. One issued and three filed patents protect the intellectual property of the ThromboLUX technology.

Successful demonstration of its usefulness also in a clinical pilot study published in Transfusion prompted Dr. Maurer to work towards making the technology widely available. With the support of CBS Dr. Maurer has founded LightIntegra Technology Inc., a Canadian company with the goal to be the world leader in platelet quality testing technology (www.lightintegra.com). LightIntegra aims to help patients worldwide by improving platelet quality for transfusion and by increasing platelet availability.

Technologies & Methods
Spin-Offs

LightIntegra Technology Inc.

Intellectual Property

ThromboLUX technology

Bio

Ph.D.(Chemistry) Karl-Franzens University Graz, Austria, 1991
Mster (Chemistry) Karl-Franzens University Graz, Austria, 1988

Publications

Selected publications

  1. Greco CA, Maurer-Spurej E, Scott MD, Kalab M, Nakane N, Ramírez-Arcos SM. PEGylation prevents bacteria-induced platelet activation and biofilm formation in platelet concentrates. Vox Sang. 2011 Apr;100(3):336-9.
  2. Lacroix R, Robert S, Poncelet P, Kasthuri RS, Key NS, Dignat-George F; ISTH SSC Workshop. Standardization of platelet-derived microparticle enumeration by flow cytometry with calibrated beads: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop. J Thromb Haemost. 2010 Nov;8(11):2571-4.
  3. Xu Y, Nakane N, Maurer-Spurej E. Novel test for microparticles in platelet-rich plasma and platelet concentrates using dynamic light scattering. Transfusion. 2011 Feb;51(2):363-70.
  4. Madsen EH, Saw J, Kristensen SR, Schmidt EB, Pittendreigh C, Maurer-Spurej E. Long-term aspirin and clopidogrel response evaluated by light transmission aggregometry, VerifyNow, and thrombelastography in patients undergoing percutaneous coronary intervention. Clin Chem. 2010 May;56(5):839-47.
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