Caloric Restriction Paradoxically Increases Adiposity in Mice with Genetically Reduced Insulin
As Published in Endocrinology by Dr. James D. Johnson
Affiliations: Diabetes Research Group, LSI
How skinny can a mouse get? Eating can cause weight loss, as can diets that lead to lower insulin levels. However, it was not known whether these had shared mechanisms or whether they would have additive effects. While completing his MSc degree, Derek Dionne and colleagues discovered the caloric restriction does not have additive effects in the context of reduced insulin. Remarkably, caloric restriction caused a paradoxical increase in fat when insulin was low.